All these meta-analyses perform tell you a dosage-reaction relationship anywhere between BP decreasing and you may potassium intake
High BP lowering having supplemental amounts off potassium about variety from 1900 in order to 4700 mg/d (49–122 mmol/d) could have been reported to result in BP decline in everything 2 so you can six mm hg getting diastolic BP and you will two to four mm hg getting systolic BP. the fresh large variability between show reflects the variability noticed in additional degree. likewise, the outcome regarding potassium to the BP is influenced by pretreatment BP level; age; race; sex; comorbid requirements; consumption off sodium, magnesium, calcium, and other ions; diet; exercise; weight; variety of potassium utilized; concomitant medications; and you can duration of have fun with. a listing of the brand new conclusions of all meta-analyses towards the aftereffects of potassium towards BP to date was provided from inside the Contour step three.
Article on meta-analyses away from degree examining https://datingranking.net/tr/waplog-inceleme/ the new blood pressure-lowering ramifications of potassium. 25–twenty-eight SBP suggests systolic blood pressure; DBP, diastolic hypertension.
Regardless if contradictory efficiency concerning your results of potassium supplementation into BP was stated from inside the clinical studies, 34, thirty-five newer trials has actually exhibited overall performance in keeping with regarding brand new meta-studies from the Whelton and colleagues twenty-six (Dining table II). Gu and you will coworkers 36 discovered that moderate potassium supplementation (sixty mmol KCl) taken to possess a dozen months lead to a decrease in systolic BP, although not diastolic BP, within the a Chinese society. Also, Kawano and you can acquaintances 37 documented you to a great cuatro-few days potassium supplements period (during which 64 mmol/d of potassium received as the sluggish-release KCl) led to quick but tall reductions in work environment, family, and 24-hours BP within the Japanese everyone. Braschi and you can colleagues 38 further checked the effect out of lower-dose potassium supplements on the BP and discovered one twenty four mmol/d away from sluggish-discharge KCl applied to possess 6 months lead to significant decrease during the indicate arterial pressure and you can diastolic BP inside suit volunteers.
Mechanisms for which Potassium Reduces BP
The brand new homeostasis of sodium and you will potassium performs an important role for the endothelium-created vasodilatation. 39 Salt retention reduces the synthesis of nitric oxide, an arteriolar vasodilator elaborated of the endothelial tissue, and you can increases the plasma quantity of asymmetric dimethyl-L-arginine, a keen endogenous inhibitor of nitric oxide production. 40 a nourishment high in potassium in addition to develops into the solution potassium, also in physiologic variety, cause endothelium-depending vasodilatation from the hyperpolarizing the endothelial telephone by way of arousal of salt pump and you may opening potassium streams. 41 On the other hand, most other advised elements where potassium can also be influence BP is natriuresis, modulation out-of baroreceptor awareness, reduced vasoconstrictive susceptibility to norepinephrine and you can angiotensin II, enhanced solution and urinary kallikrein, increased salt/potassium At Pase hobby, alteration during the DNA synthesis, and you may growth from inside the vascular easy muscles and you will sympathetic nervous system muscle. 42, 43
Fat reduction Advice getting Potassium
Maintaining an adequate intake of dietary potassium (>90 mmol [3500 mg]/d) has been recommended for the primary prevention of hypertension by the JNC 7.13 The Institute of Medicine has recommended a sodium intake <65 mmol/d (3.8 g/d) and an increase in potassium to 120 mmol/d. 44 In 2006, the American Heart Association issued new guidelines suggesting an increase in potassium intake to 120 mmol/d (4.7 g/d), which is the level provided in the DASH diets in which all food is supplied. 14 The Canadian Hypertension Society recommends that the daily dietary intake of potassium should be ?60 mmol, since this intake has been associated with a reduced risk of stroke-related mortality. 45, 46 The most recent European Society of Hypertension guidelines also support an increased potassium intake based on the DASH diet. 18 In addition, the 2003 World Health Organization/International Society of Hypertension statement recommends a diet high in fruits and vegetables, a reduction of dietary sodium intake, and increased dietary potassium intake for reducing the incidence of hypertension. 16 Some sources of high-potassium, low-sodium foods are listed in Table III. 47